Fexofenadine hydrochloride

CLINICAL USE

Antihistamine:Symptomatic relief of rhinitis and urticaria

DOSE IN NORMAL RENAL FUNCTION

120–180 mg daily depending on condition

PHARMACOKINETICS

Molecular weight :538.1

%Protein binding :60–70

%Excreted unchanged in urine : 10

Volume of distribution (L/kg) :5–6

half-life – normal/ESRD (hrs) :11–15/19–25

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function. Use with care

10 to 20 : Initial dose 60 mg once or twice daily. ‘See Other Information’

<10 : Initial dose 60 mg once daily. See ‘Other Information’

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unlikely dialysability. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unlikely to be dialysed. Dose as in GFR 10 to 20 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAluminium/magnesium containing antacids: reduced absorption – avoid for 2 hours

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

Take before food

OTHER INFORMATION

Less than 1.5% of a dose is metabolised via the CP450 3A4 systemLarger doses may be used in patients with renal impairment, but increase carefully as can result in increased sedation

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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